Rasagiline – A Dopaminergic Nootropic Drug

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Rasagiline is dopaminergic drug prescribed for the treatment and management of symptoms associated with Parkinson’s disease. It was developed by Israeli researchers working for Teva and was presented to the FDA for approval as a drug in 2004. It was approved in 2006 and is now being sold under the brand name Azilect.  Rasagiline is one of the most popular and most prescribed drugs for Parkinson’s disease. While it does not cure this medical condition, Rasagiline is very helpful in managing the shakes and tremors associated with the disease.

As a dopaminergic drug, Rasagiline is also known to be able to improve and stabilize moods and makes one feel calmer and more relaxed. Rasagiline is often used and is shown to be a more effective treatment during the early stages of Parkinson’s disease, as it has shown the ability to significantly slow down the progression of the disease. However, it also has therapeutic effects in advanced cases of Parkinson’s disease. Rasagiline also works even better when taken with supplements with L-Dopa and Carbidopa.

Rasagiline supplementsRasagiline is one of the most popular drugs developed by Teva, an Israeli pharmaceutical company that is also currently the world’s largest manufacturer of generic drugs. The company was founded in 1901 and it slowly became one of the world’s top pharmaceutical companies through the recent acquisitions of other pharmaceutical companies. The most notable of these recent acquisitions is Cephalon, the creator of arguably the most popular wakefulness promoting agents Adrafinil and Modafinil. Teva now owns the manufacturing and distribution rights for Adderall through the acquisition of Barr Pharmaceuticals.

The only prescribed medical use for Rasagiline is for the management of Parkinson’s disease symptoms like the shaking and the switching between normal movements and sudden muscle stiffness. However, other users have been experimenting with the drug as treatment for attention deficit hyperactivity disorder (ADHD). The results from users taking Rasagiline for ADHD have so far been inconclusive even in an anecdotal sense.

The mechanism of action of Rasagiline as mentioned earlier is dopaminergic, meaning it encourages the production of more of the neurotransmitter dopamine in the brain. The drug achieves this by inhibiting the production of monoamine oxidase B, which is an enzyme that degrades monoamine neurotransmitters like dopamine. Patients with Parkinson’s disease have very low dopamine levels and the use of Rasagiline along with dopamine prodrug L-Dopa, has proven to be effective in raising the dopamine levels in the brain of individuals suffering from Parkinson’s disease.

Studies have also shown that increased dopamine and norepinephrine in the brain has been shown to have a positive effect on the cognitive processes of laboratory rats and primates. This same study has even shown that it has the ability to repair impaired spatial memory in the animals. Rasagiline on the other hand was investigated on its effect on learning and memory on young and healthy laboratory rats. The study has shown that Rasagiline has clinically significant procognitive effects primarily due to its neuroprotective abilities. This not only makes it an effective nootropic, but it also shows promise as a treatment for neurodegenerative conditions.

One of the major misgivings with Rasagiline is that it interacts with a host of other drugs including antidepressants, selective serotonin reuptake inhibitors (SSRIs), other MAOIs, appetite suppressants, cold medications, stimulants, migraine medications, herbal supplements, and stimulants to name just a few. It is also important to consider the medical history of anyone who is about to use Rasagiline as the drug may prove to be dangerous for anyone with hypertension, heart conditions, diabetes, and psychological conditions. Among the side effects of Rasagiline are muscle and joint pain, pain in the digestive system, nausea, dizziness, and headaches.

PROS

  1. It has cognitive enhancing properties.
  2. It has neuroprotective abilities.
  3. It has a relaxing and anxiolytic effects.
  4. It may have other important medical applications.

CONS

  1. It is expensive.
  2. You’ll need a prescription to get one.
  3. It may not be the type of cognitive enhancer you are looking for.
  4. It interacts with a lot of other drugs and has a lot of side effects.

It will be best to consult with a physician first before you start supplementing with Rasagiline as he or she will be the most qualified to give you proper physical assessment and dosing recommendations.

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