Uridine is a type of nucleoside and along with adrenosine, guanine, and cytidine, is one of the four basic components of ribonucleic acid (RNA). There are rich food sources of Uridine and these food sources include beer, porcine and bovine liver, fish, mushrooms, broccoli, Chinese cabbage, parsley, oats, and baker’s yeast. The cognitive processes within the brain, like memory functions for instance, require a huge amount of RNA in order to make translation of protein in your synapse faster and much more efficient.
Being one of the building blocks of RNA, Uridine supplementation effectively supplies the central nervous system with enough RNA to keep the cognitive functions running smoothly right from the cellular levels. While it may be regarded as a mere “helper” in nootropic stacks, there are some studies that do suggest that it can help improve memory retention and recall even when taken on its own.
While Uridine may be present in rich quantities in common food sources, a study conducted in 1981 showed that the Uridine from most of these food sources has very poor bioavailability. Another study also discovered that some food sources like offal (e.g. liver, kidney, and pancreas) are rich in RNA, but can also increase the levels of purine in the body. High purine levels in the system jacks up the production of uric acid in the body which can lead to several health issues like gout, arthritis, and rheumatism.
The body can create its own Uridine in the liver, but the amount produced is often not enough to produce clinically significant and observable benefits. Taking Uridine supplements is therefore the best way to go in order to raise the levels of Uridine in the body enough for it to have beneficial effects.
Those who have discovered the benefits of Uridine supplementation may have also learned that this nucleoside works best along with other nootropic agents. Uridine is one of the lesser known supplements that can greatly enhance the cognitive enhancing abilities of several nootropics. This nucleoside is known to be synergistic with racetams and other nootropics that have a cholinergic action. Some studies have likewise indicated that Uridine seems to have neuroprotective benefits when used along Docosahexaenoic acid (DHA), a type of Omega 3 fatty acid.
Uridine appears to play an important role on memory formation and retention. Memories are stored in the form of connections between synapses. The development and formation of these connections require a huge amount of RNA and Uridine supplementation ensures that the CNS will have sufficient supply of it. Supplementation with RNA is all the more important because as we age, RNA is known to decrease. When supplemented along with DHA, Uridine has also been observed in animal studies to stimulate the growth of new neural connections that are essential in memory functions. Apart from these abilities, Uridine is often included in nootropic stacks for its anxiolytic effects. It is also known to help regulate sleep patterns, which means it will go well with nootropics that are known to cause sleeplessness.
One of the downsides of Uridine is that while there are a number of observational studies on the nucleoside, there is less information available as far as its use for human supplementation is concerned. The type of supplement used should also be considered as there are some forms that are not effectively absorbed by the body. There are also some studies that seem to indicate that long-term supplementation may pose some health complications. In higher dosages, Uridine has been known to cause diarrhea. Among its other side effects are headaches, upset stomach, dizziness, and nausea.
- It is an underrated yet a very effective nootropic.
- It can help improve your memory
- It can help stabilize your mood.
- Not all Uridine supplements may be bioavailable.
- Studies on its effects on humans are still lacking.
- It has its own share of unpleasant effects.
The recommended dosages for Uridine are set between 500 mg to 1.5 grams per day, preferably taken with food. Consult your doctor before starting with its supplementation.