Selank: An Anxiolytic and an Antidepressant

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Selank is yet another drug that was developed in Russia with cognitive enhancing properties that is generating positive buzz in online communities of nootropic users. Based on initial studies, Selank has shown very effective anxiolytic and nootropic properties. The drug is being eyed for the treatment and management of anxiety disorders and depression.

Along with Semax, Selank was also developed in the Institute of Molecular Genetics in Russia and according to nootropic users, the effects of these two drugs are almost the same. The only noticeable difference between the two according to those who have tried both drugs is that it would seem as if Selank was formulated primarily as an anxiolytic and as an antidepressant.

Selank

Being a heptatide, Selank has a structure sequence of Thr-Lys-Pro-Arg-Pro-Gly-Pro, which is a synthetic analog of the human peptide tuftsin. The primary mode of action of Selank was observed to be focused on stimulating the production and release of endorphins in your system. Since tuftsin is an immunomodulatory peptide, Selank has almost the same effects.

Selank also triggers the release of dopamine and serotonin, two neurotransmitters in the brain often referred to as the “feel good” hormones as they are believed to be responsible for staving off feelings of anxiety and depression. There are a few studies, which also suggest that Selank may even have anti-viral properties.

While Selank has nearly completed its third stage of clinical trials in Russia and in Europe, it has yet to be released for human use. Despite this however, some of it are already being sold by a few distributors as a nootropic agent. As of this writing, the commercially available Selank comes either in 10ml vials for intravenous and intramuscular injection, and in nasal drop/spray bottles. There are some users who don’t like to go the IV or IM route mix the 10ml with saline solution and convert it into nasal spray.

According to those who have already used Selank, its observable initial effect is one of calm mental focus and increased motivation. Some users also report of having an increased ability to learn and learn fast, the ability to memorize new data and dig up old memories, and enhanced analytical skills. These claims of cognitive enhancement are backed up by clinical studies in which lab rats exhibited 1.5-fold increase in learning capacity and an improved analytical processing. Selank was also observed to have neuroprotective and neuroregenerative properties.

The problem faced those who are planning to try out and supplement with Selank as a cognitive enhancer is that its supply is very limited and expensive. Online distributors have a very long waiting period and they can charge a very high price. Others have tried ordering pure peptides and mixed it into an IV or IM solution. While this may cut the price somewhat, you are risking infection and even necrosis if do not have training in this regard. Some users also complain of experiencing anhedonia, or the lack of motivation when the effects of this drug wanes.

PROS

  1. It appears to be an effective cognitive enhancer.
  2. Its effects are supported by actual clinical studies.
  3. It has neuroprotective and neuroregenerative properties.
  4. It has side benefits.

CONS

  1. Its supply is very limited.
  2. It is very expensive at around $400 per 500mg.
  3. Its long term effects have yet to be established.

Much like Semax, Selank is also apparently very potent requiring dosing in micrograms, microliters, or in the low milligrams. The daily recommended dosage is around 250 micrograms to 3 milligrams depending on your sensitivity to it. You can start with the lowest effective dose of about 100 micrograms and work your way up from there to determine the best dosage levels for yourself. Selank has a low toxicity profile as it has been determined that It is safe for human consumption even at 500 times higher than the normal dosing levels. As with any other drugs and supplements, it will be best to consult first with your physician before taking Selank.

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