PRL-8-53 is an investigational compound with supposed cognitive enhancing abilities. The compound is a derivative of phenylmethylamine and benzoic acid and has a chemical nomenclature of Methyl 3-[2-[benzyl(methyl)amino]ethyl]benzoate. It was developed and first synthesized in Creighton University by chemistry professor Nikolaus Hansl in the 1970s. PRL-8-53 was part of his research work on amino ethyl meta benzoic acid esters.
As obscure as this nootropic compound may sound, it has seen a few clinical studies that attests to its cognitive enhancing capacities. Preliminary studies done with animals also show that PRL-8-53 is well-tolerated and have a low toxicity profile. The study on humans involved some 47 subjects and the results on memory enhancement tests strongly suggest that PRL-8-53 has the ability to act as hypermnesic to humans.
There were very limited data that came out of the initial study on animals and humans that were conducted way back in 1978. For a substance that showed so much promise in initial human studies, it was also a bit odd that no further studies on the substance was ever conducted nor was there any effort to push for more research on PRL-8-53. Not much is also known about chemistry Professor Nikolaus Hansl who apparently passed away in November 2011.
According to living relatives of the professor, he left Creighton University in 1985 after a lawsuit. It was further explained by the relatives that studies on PRL-8-53 never got off because Hansl was not able to secure the backing or the funds necessary to get PRL-8-53 approved as a drug. It was also hinted that as potent and effective as PRL-8-53 was, Hansl was able to develop an even better and more potent compound than PRL-8-53.
An initial study conducted on laboratory mice with PRL-8-53 showed that it improved avoidance learning in rats. The human study that shortly followed, PRL-8-53 was tested on 47 healthy participants who ingested 5 milligrams of the compound orally a couple of hours prior to taking the memory tests. The participants were asked to memorize words were able to recall the words with 200% accuracy even after two weeks. The memory enhancing effects of PRL-8-53 appeared to work better on the participants who did poorly while on placebo.
As obscure as PRL-8-53 may be, it did not stop enterprising cognitive enhancing enthusiasts to have the compound synthesized in order to try it out for themselves. Users who have tried dosing with PRL-8-53 report of having enhanced mental stamina, increased in reading comprehension and speed, improved abstract coherence, more acute focus and concentration, and increased motivation. Its users specifically noted that it is indeed exceptional when it comes to memory encoding and recall. Other users report of feeling an increased motivation and theorize that this may actually be an anxiolytic property of PRL-8-53.
While everything may seem to look appear positive for PRL-8-53, one must keep in mind that there is only one study done on the substance and it was funded by the holder of the patent. No other study was ever undertaken to try to replicate the results of the study, nor was there ever any attempt to pursue it. With that said, those who are interested in trying PRL-8-53 will only have the experiences of those who have tried PRL-8-53 as reference. Some of the reported side effects from PRL-8-53 use include headaches, caustic taste, and fatigue when taken in larger doses or combined with some other nootropic agent that it doesn’t go well with.
- Study shows that it has an awesome effect on memory.
- It is very potent and requires only a small amount per dosing.
- It does have a positive effect on other cognitive processes.
- It can go well with other nootropic agents.
- It has limited human study.
- No information is available about the effects of long term use.
- Supply is very limited.
- It is very expensive to synthesize.
Assuming that you have set aside enough lunch money to have a batch synthesized for yourself, the recommended dose of PRL-8-53 is at 5 to 10mg. As always, it will be best to consult a physician first before ingesting this substance.