In 1950, Albert Hoffman discovered hydergine – that is its trademark name. This discovery was developed from a mixture of ergoloid mesylates .The guy was also responsible for discovering and developing lysergic acid diethylamide (LSD). Both the drugs, hydergine and lysergic acid diethylamide, are derived from a kind of fungus that thrives on rye. The fungus is called ergot. Hydergine’s ingredients include a mixture of methanesulfonate salts containing four dehydrogenated alkaloids from the ergot. The four alkaloids are dihydroergocristine, dihydroergocornine, alpha-dihydroergocryptine, and beta-dihydroergocryptine. Other common derivatives of ergoloid mesylate compounds available for sale are Alkergot, Cicanol, Gerimal, Hydergina, Niloric, Redergin, and Redizork. These compounds are made of disparate levels of the four alkaloids enumerated above.
Hydergine has been used in clinical environments to treat conditions such as angina pectoris, hypertension, dementia, tinnitus, peripheral vascular disease, and cognitive decline related to age. It is mostly utilized in the treatment of low blood flow to the brain (cerebrovascular insufficiency) and dementia.
How does it work?
The drug works within the central nervous system to reduce the vascular tone of blood vessels supplying the brain. Consequently, the cerebrovascular is relaxed leading to an increase in the amount of oxygen that is delivered to the neurons. Increased amount of oxygen in the brain is thought to increase neural metabolism hence function.
Certain websites vending this drug make audacious claims that it possesses a range of cellular effects. However, there is no experimental evidence that backs up their claims which mean its effect on the flow of blood remains only known credible fact. There is a study that discovered that treating aged rats with hydergine results into an increase in the number of mitochondria. These organelles produce ATP that is used to power all the cellular processes in the body.
A review of this drug in patients who possibly suffered from dementia suggested that it was more efficient that placebo. However, the effect was modest in patients even at 40mg per day. It was deemed to enhance some symptoms such as depression, dizziness, apathy and confusion, which are characteristic of or thought to be brought about by cerebral insufficiency and arteriosclerosis. It is most probably useful in the initial stages of dementia before a mass death of the neural cells has taken place.
Another study documented that this drug enhanced cognition and also reduced behavioral difficulties in children with learning disabilities. Vendors who sell these drugs advertise that they improve recall, memory and intelligence. Those who have already used hydergine report increased perception and awareness which does not necessarily translate to enhanced memories or faster-improved processing.
Hydergine side effects
Hydergine and its relations in the ergoloid mesylate class are quite safe in the therapeutic range ( the range within which the drug is active) .In large doses that are of a higher magnitude than those favorable to achieve results of enhanced blood flow to the brain, the drug is harmful.
The contraindications are ephemeral and mild. They include dizziness upon standing (orthostatic hypotension), gastrointestinal disturbances, flushing, nausea and slightly elevated heart rate.
They are very well tolerated by elderly people even when used long-term, say, five years.
Hydergine’s recommended dose is 3mg/day taken in three (1mg) doses that are divided. In Europe and Japan, doses up to 12mg per day have been used without harmful effects. A Meta review, which is a kind of study that merges the outcomes of many clinical trials, discovered that demented people were better affected by daily doses of 4.5mg or more. However, the amount is greater than what is presently recommended by US Food and Drug Administration (FDA). The percentage that reaches the plasma in blood circulation is 25 % in approximation. Peak plasma levels are attained 0.6-3.1 hours after administration. Taking it with food only slows down its rate of absorption- it does not affect the amount absorbed whatsoever. It has a half-life of between 2.6-5.1 hours. It has been confirmed that you require three to four weeks to observe any effects.
Its trademarked version is available by prescription as sublingual 0.5 and 1 mg dissolving tablets, 1 mg liquid-filled capsules, 1 mg tablets and 1 mg/ml solutions. You can buy non- prescription versions through foreign, mail order sources in 1.5, 4.5, and 5 mg tablets.
People suffering from psychosis which was previously reacted to ergoloid , or those who have low blood pressure should not hydergine.