What are Dopaminergic Nootropics?


Dopaminergic nootropics are drugs that stimulate and modulate dopamine and its receptors in various ways in order to improve cognitive functions. Similar to acetylcholine, dopamine is an important nootropic neurotransmitter that is involved in a large number of functions in terms of cognition. Dopaminergic nootropics can greatly influence focus, memory and learning . The only problem is that these types of nootropics can have potential downsides.

Mechanisms of Action

Dopaminergics are a type of nootropics that work by elevating the level of dopamine or its activity in the brain. The dopamine neurotransmitter forms part of the psychological rewards system and is responsible for causing sensations of pleasure and happiness when you win, say a competition. The nootropics work by stimulating the release of dopamine from the pre-frontal cortex .Consequently, the increased levels of dopamine in the brain can lead to enhanced energy levels, cognition and alertness in an individual. Basically, the neurotransmitter dopamine is very instrumental in all sorts of vital cognitive functions.

Examples of Dopaminergic nootropics

Mucuna Pruriens

Mucuna pruriensThis is a herbal extract that is very powerful, and it may have benefits for some people as a dopaminergic nootropic. It is rich in L-DOPA that is a natural precursor to dopamine. Suffering from low libido as well as motivation can be a symptom of lack of dopamine. In this situation, mucuna puriens can help increase the level of dopamine in one leading to extraordinary benefits as a dopaminergic nootropic. Even if dopamine levels are normal, increasing their quantity can still help with cognitive functions.


SulbutiamineSulbutiamine is a synthetic vitamin derivative that studies have shown to have stimulating effects. Its mode of action is different from the ampakines and racetams, which should be expected actually. Its mechanism of action encompasses dopamine that is a crucial neurotransmitter in the central nervous system. Sulbutiamine has been shown to increase the concentration of both D1 and D2 dopamine receptors in the brain. However, as much as it is much safer than other drugs, sulbutiamine has been registered to be potentially addictive. A buildup of tolerance has also been noted but this is always the case with other nootropics as well.


HordenineThis dopaminergic nootropic is said to stimulate the mind mildly and can be bought over the counter in many countries. However, many nutritional supplements containing hordenine label as a fat burner but there is little to no evidence which can point that hordenine’s regular oral doses have the capacity to enhance the rate of metabolism in the body. Its mechanism of action is thought to involve the inhibition of MAO-B ‘s inhibiting properties in a mild way. MAO-B is an enzyme whose function is to break down dopamine in the brain. This natural dopaminergic nootropic can also be stacked with PEA.


L-DOPA is the precursor to the neurotransmitters dopamine, norepinephrine and epinephrine which are collectively known as catecholamines. When this compound is manufactured in its pure form, it is sold as Levodopa that is used in the treatment of Parkinson’s disease symptoms. It has the capability to cross the blood brain barrier after which it is converted into dopamine. However, this increased level of dopamine in the brain may have adverse effects. Thus, levodopa is stacked with carbidopa as well as vitamin B6. When administered, this dopaminergic nootropic supplement will have both short-term effect (caused by its half-life) and a long term effect which may last for at least two weeks.

L-DopaNevertheless, this nootropic supplement has a lot of side effects including hypotension, arrhythmias and nausea which gives credence to the fact that it must be stacked.


Rasagiline supplementsThis dopaminergic drug is recommended for the treatment of Parkinsonism. It is very essential in managing the shakes and tremors associated with the condition. Dopaminergically, rasagiline has been shown to enhance steady moods and particularly sharp in the primary stages of Parkinson. It works even better when stacked with other supplements such as carbidopa and L-DOPA.


SelegilineSelegiline is also a dopaminergic nootropic that is used to treat Parkinson’s disease. In a way that is akin to hordenine, it works by inhibiting the monoamine oxidase enzymes. The drug can either be used alone as well as being stacked along with other supplements like levodopa to elicit the desired effects.


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